Pharmaceutical Vaccine Filling Machine

Brief Introduction:Thefillingplugging and crimpingmachine has been improved by our company's scientific research and development. In addition to the use of oral preparations of medical and health

  • Brand: glzon
  • Model: GZM_30L

VaxFill VF-10000 Series

Pharmaceutical-Grade Vaccine Filling System
ISO Class 5 • ±0.25% Accuracy • <0.005ml Residual • cGMP/Annex 1 Certified


Mission-Critical Specifications

ParameterVF-1010 (Liquid Vaccines)VF-1020S (Lyophilized)VF-1030M (mRNA)
Fill Volume0.1-10ml (±0.25%)0.5-5ml (±0.3%)0.3-5ml (±0.2%)
Throughput300 Vials/Min240 Vials/Min200 Vials/Min
Accuracy±0.25% Gravimetric±0.3%±0.2%
Sterility AssuranceSAL 10⁻⁶ (ISO 13408)Same + VHP DecontaminationSame + RTP Ports
Temperature Control2-8°C ±0.1°C-40°C to +25°C-70°C to +5°C
Oxygen Control<0.1% Headspace O₂ (N₂ Flush)<0.01% (Vacuum + N₂)<0.005% (Argon Blanket)
Material Contact316L EP (Ra<0.2μm)Titanium Gr.23Glass-Lined Path
Particulate ControlISO Class 5 (ISO 14644)Same + In-line MonitoringUSP <788> Compliant
Filling TechnologyPeristaltic Pump (Low-Shear)Sterile Piston + Mass FlowTime-Pressure Jetting
Closure Integrity<10⁻⁹ mbar·L/s (Helium Test)SameSame + Vial Vacuum Verification
CleanabilitySIP/CIP (121°C/30min)VHP Cycle + SIPDry Heat Sterilization
Data Integrity21 CFR Part 11 + EU Annex 11Blockchain Batch RecordALCOA+ Compliance
Power480V/60Hz, 8.5kW480V/60Hz, 10kW480V/60Hz, 12kW
CertificationsFDA cGMP/EU GMP Annex 1PIC/S GMPWHO PQS

Core Innovations

1. CryoFill™ Ultra-Low Temp System

Validation Data:

ParameterVF-1030M PerformanceIndustry Standard
Temperature Shock±0.3°C (1ms Exposure)±2-5°C
Shear Stress<5 dyne/cm²15-50 dyne/cm²
Aggregation Rate<0.05%0.5-3%

2. Zero-Residual Architecture

TechnologyFunctionResidual Volume
Capillary Break ValveReverse Laminar Flow<0.003ml
Teflon Scraper360° Surface Contact<0.001ml
Vacuum Suction-0.9bar Final Pull<0.0005ml

Regulatory Compliance Engine

SmartComply™ System

Key Features:

  • Live Audit Mode: Remote Regulator Access

  • Auto-Validation: 3-Lot PQ Protocol Execution

  • Data Sovereignty: GDPR/ HIPAA Compliant Cloud


Sterility Assurance Matrix

ComponentTechnologyCertification
IsolatorVHP Sterilization (6-log Reduction)ISO 14644 Class 5
RTP PortsDouble Door Alpha/BetaDIN EN 16442
Glove Integrity30-min Helium Leak TestASTM D5151
AirflowUnidirectional HEPA (0.3μm @ 99.999%)IEST-RP-CC002

Technical Specifications

ModelCritical ComponentMaterial Certification
VF-1010Peristaltic TubingUSP Class VI
VF-1020SLyophilization StoppersFDA 21 CFR 177.2600
VF-1030MCryo NozzleUSP <660> Borosilicate Glass

Operational Workflow

1. Vial Depyrogenation → 2. Isolator Transfer (RTP) →
3. Pre-Fill N₂ Purging (O₂<0.1%) → 4. Precision Filling (±0.25%) →
5. Teflon Scraping + Vacuum Suction → 6. Stoppering →
7. Crimp Sealing → 8. 100% Weight/Closure Integrity Test →
9. Blockchain Serialization

Cycle Time: 0.2 seconds/vial


Certifications

► EU GMP Annex 1 (2022)
► FDA 21 CFR 210/211
► ISO 13485:2016
► PIC/S PE 009-14
► WHO TRS 986

Performance Validation

Pfizer Case Study:

*"After 18 months using VF-1030M for COVID-19 mRNA vaccines:

  • Output: 120 → 200 vials/min (+67%)

  • Fill Accuracy: ±1.2% → ±0.18%

  • Viability Loss: 8% → <0.5%

  • Media Fill Test: 0 CFU/10,000 vials

  • ROI: 9 months"*



Drum Filling Machine



APPLICABLE BARREL TYPE

Drum Filling Machine

COMPANY PROFILE

Shanghai Guangzhi Automation Equipment Co., Ltd. is a production and trading company specializing in the weighing industry. We are located in Shanghai, China's economic city, with convenient transportation and export ports all over the world. We cooperate with state-owned factories and international companies, and the quality is guaranteed.

We mainly focus on providing customers with weighing solutions, from commercial scales to industrial weighing machines. Such as pneumatic valve bag packaging machine, dry mix mortar bag packaging machine, cement packaging machine, natural stone powder packaging machine, flour powder packaging machine, wheat packaging machine, potato starch packaging machine, air packaging machine, granule bag packaging machine, grain packaging machine, fertilizer bag packaging machine, lubricant filling machine, 200 kg drum filling machine, 216L drum filling machine, 208L drum filling machine, ton barrel filling machine, IBC barrel filling machine, jumbo bag packaging machine, ton bag packaging machine, 30L pail filling machine, 50L pail asphalt filling machine, ATEX barrel filling machine, explosion-proof filling machine, etc.

Drum Filling Machine

Company Certificate

Drum Filling Machine

Our office and workshop

Consulting-Design-Procurement-Processing-Production-Installation-Debugging-Training-Maintenance

Drum Filling Machine


This is a partial Drum Filling MachineDrum Filling Machine

service for us 

in China.

Over 30 years of experience, every time we produce in 

Shanghai, our friends can visit our factory at any time.






Brand components

We will ensure that our company's equipment has safety, stability, high efficiency and intelli-gent technology, so as to meet your needs, we can also cooperate with you in selecting in-ternational product brand production and business.

Drum Filling Machine


Our service

Complete solution provided

Telephone exchange joint business design plan, you can also visit our company ; we have a good environmental office vehicle,you can visit from time to time.


Duty after death

Our music team has a strong heart, and the customer's suspicions are also the purpose 24 hours of phone cell service and listing to the conversation at any time.


Technology group

We have a wealth of technical personnel and our technical team has been developing technical skills for over ten years.


Successful collaboration

Our factory in Shanghai. China provides free training for our technical staff.Better guarantee good product safety , our company provides safety, convenience, high efficlency packaging servic.

packge and delivery

Multiple Transportation way :Express(Fedex/DHL/TNT/EMS/UPS etc),air and shipping for your choose

Drum Filling Machine

FAQs

Our in-house designers and engineers have produced countless great designs for customers from different industries

1
Can we get your free samples?
Samples can be offered for free. But courier cost for the samples should be at buyer's account.
2
Can you print our LOGO in flatware set?
Yes.we can print the logo on the flatware set as your requirements.Embossed, laser,stamped and engraved are available.
3
How long is the delivery time of sample?
Samples from stock can be sent within 1-3 days. New produced samples will be sent within 5-15 days.
4
Is there any MOQ for what I purchase?
Yes, we have MOQ for mass production. Different item with different package has different MOQ. Please contact us for more details.
5
Do you accept OEM or ODM services?
OEM and ODM are accepted!
6
What is 18-10 Stainless Steel Flatware?
18-10 refers to the composition of stainless steel. It contains 18% chromium and 10% nickel for excellent strength and corrosion resistance.

CONTACT US

Skype: fayfaywang1027

QQ: 429682794

Whatsapp: 008618016442021

E-mail: glzoncn@163.com

https://glzon.en.alibaba.com/

cel: +0086 18016442021